Simon P Newman Selected Research

STX 213

9/2008	Efficacy of three potent steroid sulfatase inhibitors: pre-clinical investigations for their use in the treatment of hormone-dependent breast cancer.
9/2006	In vivo efficacy of STX213, a second-generation steroid sulfatase inhibitor, for hormone-dependent breast cancer therapy.

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Simon P Newman Research Topics

Disease

17	Breast Neoplasms (Breast Cancer) 01/2013 - 01/2002
16	Neoplasms (Cancer) 04/2014 - 02/2005
3	Prostatic Neoplasms (Prostate Cancer) 02/2014 - 09/2007
1	Hypoxia (Hypoxemia) 10/2015
1	Neoplasm Metastasis (Metastasis) 01/2013
1	Peripheral Nervous System Diseases (PNS Diseases) 01/2013
1	Neutropenia 01/2013
1	Vascular Diseases (Vascular Disease) 01/2011
1	Type 2 Diabetes Mellitus (MODY) 01/2011
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 08/2008
1	Choriocarcinoma 03/2006

Drug/Important Bio-Agent (IBA)

8	2- methoxyestradiol- 3,17- O,O- bis(sulfamate)IBA 10/2015 - 01/2006
8	Hormones (Hormone)IBA 01/2013 - 02/2005
5	2-MethoxyestradiolIBA 10/2015 - 02/2003
5	Steryl-Sulfatase (Steroid Sulfatase)IBA 09/2008 - 02/2005
4	Messenger RNA (mRNA)IBA 05/2008 - 03/2006
3	Proteins (Proteins, Gene)FDA Link 10/2015 - 05/2008
3	SteroidsIBA 04/2014 - 09/2006
3	sulfamic acid (ammonium sulfamate)IBA 02/2014 - 02/2005
3	EnzymesIBA 10/2008 - 01/2002
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2013 - 01/2008
2	SulfatasesIBA 10/2008 - 09/2006
2	Aromatase (CYP19)IBA 10/2008 - 01/2002
2	STX 213IBA 09/2008 - 09/2006
2	Estradiol (Delestrogen)FDA LinkGeneric 09/2008 - 05/2008
2	Estrogens (Estrogen)FDA Link 02/2005 - 01/2002
1	2-ethyloestradiol-bis-sulfamateIBA 10/2015
1	7- methoxy- 2- (3- methoxybenzyl)- 6- sulfamoyloxy- 1,2,3,4- tetrahydroisoquinolineIBA 02/2014
1	1,2,3,4-tetrahydroisoquinolineIBA 02/2014
1	Glucose (Dextrose)FDA LinkGeneric 01/2011
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2011
1	Caspase 3 (Caspase-3)IBA 10/2009
1	2- methoxy- 3- O- sulfamoyl- 17- cyanomethylestra- 1,3,5(10)- trieneIBA 10/2009
1	SurvivinIBA 10/2009
1	Letrozole (Femara)FDA LinkGeneric 10/2008
1	Estrogen ReceptorsIBA 10/2008
1	Androstenedione (4 Androstene 3,17 dione)IBA 10/2008
1	Sulfates (Sulfates, Inorganic)IBA 10/2008
1	2- methoxyestradiol- 3,17- bis- O,O- sulfamateIBA 09/2008
1	Angiogenesis InhibitorsIBA 09/2008
1	2-ethylestradiol sulfamateIBA 09/2008
1	N- (2- fluoro- 4- (4- (2- (phenoxymethyl)- 1H- imidazol- 4- yl)phenoxy)phenyl)sulfamideIBA 08/2008
1	TubulinIBA 08/2008
1	2- ethyl- 16- ((3- pyridylmethylamino)carbonylmethyl)estroneIBA 05/2008
1	3 (or 17)-beta-hydroxysteroid dehydrogenaseIBA 05/2008
1	2- methoxyoestra- 1,3,5(10),16- tetraene- 3- carboxamideIBA 05/2008
1	Complementary DNA (cDNA)IBA 05/2008
1	Small Interfering RNA (siRNA)IBA 05/2008
1	Antineoplastic Agents (Antineoplastics)IBA 03/2008
1	taxaneIBA 01/2008
1	Docetaxel (Taxotere)FDA Link 01/2008
1	Carbonic Anhydrases (Carbonic Anhydrase)IBA 09/2007
1	estradiol sulfateIBA 09/2006
1	Oxidoreductases (Dehydrogenase)IBA 01/2006
1	Estrone FDA Link 02/2005
1	2-methoxyestroneIBA 04/2004
1	Dinoprostone (PGE2)FDA Link 01/2002
1	CytokinesIBA 01/2002

Therapy/Procedure

3	Therapeutics 05/2008 - 02/2005
2	Injections 10/2008 - 09/2006
1	Withholding Treatment 09/2007